a) All the various cell types in a typical carcinoma, including fibroblasts, inflammatory cells, and blood, vessels, evolve from the cancer cell population. False. The cancer-cell does regulate e.g. the agiogenesis but the cells therefore are not derived from the original cancer cell. b) Genetic instability in the form of point mutations, chromosome rearrangements, and epigenetic changes needs to be maximal to allow the development of cancer. cancer than individuals with two nonmutant copies. False. Genetic instability increases the risk of getting cancer, but it is not necessary (e.g. ERVs) c) Cancer therapies directed solely at killing the rapidly dividing cells that make up the bulk of a tumor are unlikely to eliminate the cancer from many patients. True. This method of killing the cancer is made especially for an individual cancer cell; other patients most likely have other mutations on which this method will not operate. d) Individuals who inherit one inactive copy of a tumor suppressor gene are more likely to develop True. With the inactive copy damaged DNA won't be repaired; With the two copies repairing is ensured